HS071, A New Furan-type Cytotoxic Metabolite from Streptomyces sp. HS-HY-071
نویسندگان
چکیده
منابع مشابه
Antioxidant and cytotoxic activities of metabolites produced by a new marine Streptomyces sp. isolated from the sea cucumber Holothuria leucospilota
Marine microorganisms are important sources for novel natural products. Hence, the aim of this study was introducing the marine microorganisms with capability to produce antioxidant and cytotoxic metabolites. For this purpose, ten live sea cucumbers (Holothuria leucospilota) were collected from Larak Island. Then, their intestine contents were serially diluted and treated by heating (55 °c). 10...
متن کاملAntioxidant and cytotoxic activities of metabolites produced by a new marine Streptomyces sp. isolated from the sea cucumber Holothuria leucospilota
Marine microorganisms are important sources for novel natural products. Hence, the aim of this study was to introduce marine microorganisms with the capability of producing antioxidant and cytotoxic metabolites. For this purpose, ten live sea cucumbers (Holothuria leucospilota) were collected from Larak Island, Persian Gulf. Then, their intestine contents were serially diluted and treated by he...
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(Traders) 1.0%, yeast extract 0.1%, and CaCO3 0.2% (pH 7.2). The fermentation was carried out at 28°C on a rotary shaker (180 rpm) for 96 hours. The culture broth of Streptomyces sp. AJ9561 (5 liters) was filtered to obtain mycelium, which was extracted with acetone (3 liters) at room temperature. The extract was concentrated in vacuo to an aqueous suspension, which was extracted with EtOAc (50...
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During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strain Streptomyces sp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues 2-8 was isolated and identified from the culture broth. Their chemical structures were determined by detailed analy...
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A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cyt...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2008
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2008.82